Ghirlandaio's full name is given as Domenico di Tommaso Curradi di Doffo Bigordi, it appears, therefore, that his father's surname was Curradi and his grandfather's Bigordi. Domenico, the eldest of eight children, was at first apprenticed to a jeweller or a goldsmith, most likely his own father. The nickname "Il Ghirlandaio" (garland-maker) came to Domenico from his father, a goldsmith who was renowned for creating the metallic garland-like necklaces worn by Florentine women. In his father's shop, Domenico is said to have made portraits of the passers-by, and he was eventually apprenticed to Alessio Baldovinetti to study painting and mosaic
In 1480, Ghirlandaio painted the Saint Jerome in His Study and other frescoes in the Church of Ognissanti, Florence, and a life-sized Last Supper in its refectory. From 1481 to 1485, he was employed on frescoes in the Sala dell Orologio of the Palazzo Vecchio. He also painted the Apotheosis of St. Zenobius, an over-life-sized work with an elaborate architectural framework, figures of Roman heroes, and other secular details, striking in its perspective and structural/compositional skill.
In 1483, Ghirlandaio was summoned to Rome by Pope Sixtus IV to paint a wall fresco in the Sistine Chapel, Christ calling Peter and Andrew to their Apostleship. His other works in Rome are now lost. Before 1485, he produced frescoes for Cappella di Santa Fina, in the Tuscan Collegiata di San Gimignano which, after circa 1350, was under the rule of nearby Siena. His future brother-in-law, Sebastiano Mainardi, assisted him with these commissions in Rome and in San Gimignano.
Back in Florence in 1485, Ghirlandaio painted fresco cycles in the Sassetti chapel of Santa Trinita for the donor and banker Francesco Sassetti, the powerful manager of the branch of the Medici bank in Genoa, a position subsequently filled by Giovanna Tornabuoni - Ghirlandaio's future patron. In the chapel, Ghirlandaio painted six scenes from the life of Saint Francis, including Saint Francis obtaining from Pope Honorius the Approval of the Rules of His Order, Death and Obsequies and Resuscitation, by the interposition of the beatified saint, a child of the Spini family, who died as a result of a fall from a window. The first work depicts a portrait of Lorenzo de Medici, and the third, the painter's own likeness, which he also included in one of his pictures in the Santa Maria Novella as well as in the Adoration of the Magi in the Ospedale degli Innocenti orphanage. The altarpiece from the Sassetti chapel, the Adoration of the Shepherds, is now in the Florentine Academy.
Immediately after this commission, Ghirlandaio was asked to renew the frescoes in the choir of Santa Maria Novella, which formed the chapel of the Ricci family, but the Tornabuoni and Tornaquinci families, then much more prominent than the Ricci, undertook the cost of the restoration, with conditions-the question of preserving the arms of the Ricci gave rise to some amusing litigation. The Tornabuoni Chapel frescoes, by Ghirlandaio and many assistants, were painted in four courses along the three walls, the main subjects being the lives of theMadonna and St. John the Baptist. These works are particularly interesting in that they include many historical portraits, a genre in which Ghirlandaio was preeminently skilled.
In this cycle, there are no fewer than twenty-one portraits of the Tornabuoni and Tornaquinci families: in the Angel appearing to Zacharias, portraits of Politian, Marsilio Ficino, and others, in the Salutation of Anna and Elizabeth, the beautiful Giovanna Tornabuoni (wrongly attributed by Giorgio Vasari as Ginevra de Benci), in the Expulsion of Joachim from the Temple, (Sebastiano) Sebastiano Mainardi and Baldovinetti (or the latter figure may, perhaps, be Ghirlandaio's father). The Ricci chapel was completed in 1490, the altarpiece was probably executed with the assistance of Domenico's brothers, Davide and Benedetto, the painted window was from Domenico's own design.
Other distinguished works from Ghirlandaio's hand are an altarpiece in tempera of the Virgin Adored by Saints Zenobius, Justus and Others, painted for the church of Saint Justus, but now in the Uffizi gallery, a remarkable masterpiece, Christ in Glory with Romuald and Other Saints, in the Badia of Volterra, the Adoration of the Magi, in the church of the Innocenti (already mentioned), perhaps his finest panel-picture (1488), and the Visitation (Louvre) which bears the last ascertained date (1491) of all his works. Ghirlandaio did not often attempt the nude-one of his pictures including nudes, Vulcan and His Assistants Forging Thunderbolts, was painted for Lorenzo II de' Medici, but (like several others specified by Giorgio Vasari) no longer exists. The mosaics that he produced date before 1491-one, of special note, is the Annunciation, on a portal of the cathedral of Florence.
Ghirlandaio's compositional schema were simultaneously grand and decorous, in keeping with the 15th century's restrained and classicizing experimentation. His chiaroscuro, in the sense of realistic shading and three-dimensionalism, was reasonably advanced, as were his perspectives, which he designed on a very elaborate scale by eye alone, without the use of sophisticated mathematics. His color is more open to criticism, but this remark applies less to the frescoes than the tempera paintings, which are sometimes too broadly and crudely bright. His frescoes were executed entirely in what the Italians term buon fresco, without additions in tempera.
A certain hardness of outline may attest to his early training in metal work. Vasari says that Ghirlandaio was the first to abandon, in great part, the use of gilding in his pictures, representing by genuine painting any objects supposed to be gilded, yet this claim is not applicable to his entire oeuvre, since the landscape highlights in, for instance, the Adoration of the Shepherds, now in the Florence Academy, were rendered in gold leaf. Many drawings and sketches by this painter, now in the Uffizi gallery, are particularly remarkable for their naturalistic vigor of outline.
One of the great legacies of Ghirlandaio is that he is commonly credited with having given some early art education to Michelangelo, who cannot, however, have remained with him long. Among other pupils were Francesco Granacci.
Ghirlandaio died of "pestilential fever" and was buried in Santa Maria Novella. The day and month of his birth remain undocumented, but since he died in early January, he most likely did not reach his forty-fifth birthday. He had been twice married and left six children, three of them sons. Ridolfo, in particular, was also a painter. He had a long line of descendants, but the family died out in the 17th century, when the last members entered monasteries.